Consequence of Tetrapleura tetraptera Leaves on Pro-Oxidants, Hepatic Functions and Histomorphology in Monosodium Glutamate-Intoxicated Rats

Background and Objective: Medicinal plants contain bioactive components which play important roles in the prevention and management of ailments. Tetrapleura tetraptera which is a known medicinal plant contains bioactive components which could play vital roles in the prevention and management of hepatic injuries. Thus, warranting this study aimed at investigating the effects of Tetrapleura tetraptera leaves on hepatic architecture and antioxidant activities in monosodium glutamate-intoxicated rats. Materials and Methods: The liver enzyme activities and antioxidant potential of Tetrapleura tetraptera leave on normal and intoxicated rats were determined using standard protocols. The SPSS Version 22 was used for the One-way ANOVA analysis. Results: The results of the liver enzymes indicated a significant (p<0.05) decrease across all the co-treated groups as against the monosodium glutamate groups. The co-treated groups also showed significant (p<0.05) improvement in the serum antioxidant activities while also showing higher reducing power than the standard (vitamin C and garlic). The portal veins of the hepatic histopathological examination indicated normal blood flow without congestion in the normal and Tetrapleura tetrapteraleaves ethanol extract groups while indicating full congestion of the portal vein in the monosodium glutamate group. However, the co-treated groups showed reduced congestion seemingly supporting the serum chemistry results indicating improved renal function. Conclusion: Tetrapleura tetrapteraleaves ethanol extract to have high antioxidant properties and reversed hepatic injury induced by monosodium glutamate.